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Erastin and its analogs, sulfasalazine and sorafenib, as small molecule inhibitors of system ( SLC7A11 ), have been developed

10.1016/j.tips.2004.09.007 193 TheoharidesT

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Two controlled studies concluded DSIPs sleep effect was of little clinical significance [11] and not likely to be of major therapeutic benefit. [12] That combination minutes-long half-life, non-monotonic dose-response, delayed and persistent effects, and failed replication is precisely why the field stopped