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[6] The Trx system exists in all living cells and has an evolutionary history tied to DNA as a genetic material, defense against oxidative damage due to oxygen metabolism, and redox signaling using molecules like hydrogen peroxide and nitric oxide

Romei MG et al incorporated site-specific substitutions of 10 non-canonical amino acids into photoswitchable green fluorescent protein Dronpa2 using five different aminoacyl-tRNA synthetases (aaRSs) and their corresponding tRNA CUA to study photoisomerization in proteins [37]

However, whether GGT has a direct role in the pathophysiology of CVD or it is an epiphenomenon of coexisting CVD risk factors or comorbidities remains unknown and Hills criteria of causality relationship between GGT and CVD are not fulfilled

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