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To view a copy of this licence, visit About this article Cite this article Gharib, F.A.E.L., Osama, k., Sattar, A.M.A.E

Expression of D620N VPS35 in cortical neurons led to impaired neurite outgrowth and induced dopaminergic neurodegeneration in a novel virus-mediated rat model ( + ) and rotenone was significantly increased in the overexpression of WT and D620N VPS35 models ( via formation of mitochondrial-derived vesicles (MDVs) and played an important role in mediating transport of the vesicles from mitochondria to peroxisomes and lysosomes ( VPS35 mutations resulted in mitochondrial fragmentation and neuronal loss in neurons in vivo and in vitro (Wang et al., 2016)