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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Journal of Biological Chemistry, 250(4), 1422-1426

The highest second order rate constant k red of 1.4 10 6 M 1 s 1 was determined for the reaction between PfGrx C88S (SH) 2 and roGFP2 C208S (SSG) (Fig