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J Clin Invest (2014) 124(8):366777

Marzola P, Degrassi A, Calderan L, Farace P, Crescimanno C, Nicolato E, Giusti A, Pesenti E, Terron A, Sbarbati A, et al

TLR4, MyD88, and IRAK4 form a complex called the middosome, that acts as a platform to recruit other members of the IRAK family, such as IRAK1 and IRAK2