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the clinical significance in humans remains under investigation and is not yet established for retatrutide specifically [24] [25] Other class-associated cautions: Based on the broader GLP-1/GIP receptor agonist class, potential effects on gallbladder function and delayed gastric emptying are relevant considerations, though evidence specific to retatrutide is still emerging It is important to note that this evidence derives from early-phase trials conducted under controlled conditions with medical supervision

doi:10.3389/fphar.2020.585838

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Functionally, MAPKAPK2 overexpression significantly ameliorated H 2 O 2 -induced phenotypes, including reduced viability, increased apoptosis, impaired melanogenesis, and elevated ROS levels accompanied by reduced antioxidant capacity (GSH and SOD)