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QiDiTangShen granules modulated the gut microbiome composition and improved bile acid profi les in a mouse model of diabetic nephropathy

While this broad pattern remains consistent, the distribution of gut bacteria varies both over time and along the digestive tract, with significant differences in diversity and bacterial counts as moving from the esophagus down to the colon and distal gut as depicted in Fig

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Some evidence suggests this drop may begin around age 45coinciding with the transition into perimenopause