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The author would like to thank Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) for the productivity fellowship (CNPq 307022/2022-6)

The treatment of penicillin or tetracycline can cause a JarischHerxheimer reaction (JHR), which can lead to acute respiratory distress syndrome (ARDS) and multi-organ failure in severe cases

This superimposed oxidative/nitrative stress could ultimately push the cell across the threshold to observable injury. SUPEROXIDE DAMAGE OF MITOCHONDRIAL DNA Superoxide is a powerful oxidant that is quite toxic

Castilla-Cortazar I, Diez N, Garca M, Puche JE, Diez-Caballero F, Quiroga J, Diaz-Sanchez M, Castilla A, Casares AD, Varela-Nieto I, Prieto J, Gonzalez-Baron S: Hematotesticular barrier is altered from early stages of liver cirrosis