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doi:10.1155/2013/485341 Giloteaux L, Goodrich JK, Walters WA, Levine SM, Ley RE, Hanson MR

In severe cases, can even cause blockages

Published 2017 Jun 28

3.2 Metformin inhibits the TGF-1/Smad3 pathway Another mechanism of HSC activation is the cooperation of TGF-1-related signaling pathways and other signals, including ROS, PDGF, and connective tissue growth factors (66)