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Vitamin E (800 IU daily) has some evidence supporting its use in non-diabetic adults with biopsy-proven NASH, but this is specialist-initiated, off-label use requiring discussion of potential risks, including increased risk of haemorrhagic stroke and prostate cancer with long-term use

Free radicals, owing to their instability and consequent erratic behavior, have the potential to cause cell damage that would be virtually unlimited without antioxidants to hold their numbers in check and glutathione, which is the only antioxidant that is known to occur naturally within the cells is the master antioxidant. Although it was first identified in 1888, it was not until almost a century later that scientists began to undertake through investigations into the role that it plays in human metabolism

Multiple meta-analyses have found that smokers have significantly lower sperm count, poorer motility, greater morphological abnormalities, and higher rates of DNA fragmentation compared to non-smokers

Doshis note: There is no single best form of glutathione for everyone