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More rigorous pre-clinical and clinical research studies need to be conducted before Thymoquinone/Nigella sativa can be routinely used as an effective complementary or alternative treatment

[DOI] [PubMed] [Google Scholar] 176.Olivan-Blazquez B., Montero-Marin J., Garcia-Toro M., Vicens-Pons E., Serrano-Ripoll M.J., Castro-Gracia A., Sarasa-Bosque M.C., Mendive-Arbeloa J.M., Lopez-Del-Hoyo Y., Garcia-Campayo J

Conversely, we have also demonstrated that exacerbated activation of the BH4 pathway is pathogenic, causing mitochondrial dysfunction, increasing the aggressiveness of the immune system, inducing pain hypersensitivity, and the progression of symptoms of chronic diseases, including chronic pain, asthma, multiple sclerosis, ulcerative colitis, rheumatoid arthritis, cognitive impairment, and others [83,84,85,86,87]

Genetic predispositions constitute a smaller but clinically important share of RCC cases