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Description

10.1210/er.2015-1104 Endocr Rev

The hypothesis for PD-1/PD-L1 blockade focuses on the infiltration of activated T cells and inflammatory changes that lead to all-trans-Retinoic acid (ATRA)- and IFN--mediated CD38 upregulation, which mediates immunosuppression via adenosine production and its effect on CD8 + cytotoxic T cells [114]