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Description

Although some tantalizing findings have been reported, the final proof to demonstrate the key role of increased intestinal permeability in IBS has yet to be provided

FIGURE 10 4 Discussion Deg-AZM, a new Class I drug for clinical treatment of STC, was found to stimulate the expression of transgelin in intestinal smooth muscle cells, promote the polymerization of G-actin into F-actin, increase the formation of stress fiber bundles in intestinal smooth muscle cells, and promote intestinal peristalsis ( In the early stage of drug development, comprehensively elucidating the ADME properties of the drug candidate in animals is a crucial prerequisite for understanding its efficacy and safety ( in vivo and in vitro