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Pulmonary hypertension is associated with the development of cor pulmonale, defined as hypertrophy of the right ventricle resulting from diseases affecting the function and/or structure of the lungs, except when these pulmonary alterations are the result of diseases that primarily affect the left side of the heart, as in congenital heart disease. This is a pathological definition and the clinical diagnosis and assessment of right ventricular hypertrophy is difficult in life

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In the prenatal period, the entire meniscus is vascularized and becomes more and more localized as the knee matures