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described two different mechanisms through which ALA induces glucose uptake: ALA induces PI3K and AKT phosphorylation, which determine GLUT4 translocation and it also increases p38 MAPK activity, which determines GLUT4 activation [2]

(205) and Moore et al

eds.), pp

499 Measurements of NA-induced changes in cyclic adenosine monophosphate (cAMP) revealed an increased sensitivity of this second messenger to changes in extracellular lactate, indicating altered signalling landscape at the plasma membrane in relation to lactate homoeostasis