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Emerging evidence also indicates an increased risk of HA in patients treated with VPA and carbonic anhydrase inhibitors (CAIs) such as topiramate (TPM) and acetazolamide (ACZ) [15,16,17]

For patients with significant weight loss goals, FDA-approved options backed by stronger clinical evidence may be more appropriate as a primary treatment

(4) The hydrolytic stability and reactivity of the PEG modifier depend on the stability of the activating group and the control of the modification reaction conditions, especially the pH

Mitochondrial abnormalities have also been associated with point mutations in Hsp70 chaperone that makes it aggregation prone, thereby, increasing iron and free-radical load 15,16,17