foxo4-dri clinical trial

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Description

The treatment difference of 17.3 percentage points versus placebo represents the largest weight reduction achieved by any pharmacotherapy in a Phase 3 trial

Analgesic amounts stimulated respiration via central mu1 receptors, cataleptic amounts depressed breathing and blunted the CO2 response, and the peptide lowered blood pressure documenting the dose-dependent opioid effects including respiratory depression