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The proteasome inhibitor lactacystin was applied to a rat model of IRI, which resulted in a decrease in ET-1 levels and a delay in the decline of renal function[29]

This pro-angiogenic effect involves stimulation of vascular endothelial growth factor (VEGF) production and activation of endothelial cells to proliferate, migrate, and form new capillary networks

Limited availability of cellular Zn due to Zn deficiency could result in a loss of activity of these Zn dependent proteins involved in the maintenance of DNA integrity and may upregulate expression of the tumor suppressor protein p53, but impair the DNA binding abilities of p53, nuclear factor kB (NFkB) and AP-1 transcription factors [139]