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Open pores effectively increase the surface area of the specimen and, thus, the reactive surface area, which is susceptible to water degradation

baseline mean problem score 14, dropping to 6 at week 12, rising to 9 two weeks post CyA discontinuation

In some instances, bimodal formulations allow for a constant rate of release of an immediate release component (multiparticulate agent (e.g., micronized active agent)) and a constant rate of release of an extended release component (e.g., an encapsulated active agent that serves as a depot for extending the release of an active agent)

For established keloids, other treatments remain the primary approach