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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

Meanwhile, the high expression efficiency and high yield of recombinant polypeptides give them certain advantages in the research and development of new drugs

This gene plays a role in peptide trimming for MHC class I presentation, and variations in ERAP1 may affect the immune response to self or foreign antigens, which might be associated with the pathogenesis of psoriasis (44)