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I dont think there are studies showing clear long-term benefits yet. Instead, Reddy points to far less glamorous interventions: sleep, exercise, and eating healthy

Iran_J_Immunol, IJI

Double-blind, placebo-controlled studies are available for only a few symptomatic treatments, such as botulinum toxin for sialorrhea [54] and dextromethorphan plus quinidine for pseudobulbar affect [55]