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Lymphangiogenesis is regulated by a variety of growth factors, of which VEGF-C and VEGF-D, which recognize the vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of lymphatic endothelial cells, are the most important (104)

The animals were anesthetized by inhalation route with Isofluorane (Isboa Vet) using a vaporizer and intranasal administration was performed with two instillations of 20 l of the bacterial suspension prepared in PBS