Complementation results of lgt -knockout cells with different mutant Lgt variants revealed critical residues, including Arg143 and Arg239, that are essential for diacylglyceryl transfer
Platinum sensitivity of ovarian cancer cells does not influence their ability to induce M2-type macrophage polarization
Amyotrophic lateral sclerosis The molecular mechanism of excitotoxicity in ALS involves the excessive release of glutamate, causing Ca 2+ overload and excessive activation of the glutamate receptor AMPA, thereby inducing astrocyte proliferation, mitochondrial dysfunction, and energy exhaustion
Specifically, chondrocytes exposed to ferric ammonium citrate (FAC) exhibit increased expression of FTH1 and reduced levels of transferrin receptor 1 (TfR1) and hepcidin, whereas ferroportin (FPN1) expression remains unchanged ( 3.3.2 Fenton reactions and the bidirectional effects of iron homeostasis imbalance Free Fe + participates in the Fenton reaction, leading to the generation of hydroxyl radicals (OH), which represents a crucial step in initiating the lipid peroxidation chain reaction ( 3.3.3 Local iron homeostasis and the joint microenvironment Pathological changes such as increased vascular permeability or microbleeding in subchondral bone can also lead to local iron deposition
