ipamorelin prolactin cortisol increase effects on levels ipamorelin effects on cortisol and Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety CJC-1295/Ipamorelin Dosage: Dosing & Cycle – ipamorelin cortisol prolactin study human

Consistency is keyregular use will maximize the brightening effects over time

(85 g) provides 833% of the DV (22,24)

Disclosures: Joanne Hsieh: Gordian Biotechnology: Employee, Vinay Kartha: Nothing to Disclose, Hikaru Miyazaki: Nothing to Disclose, Christopher Carrico: Nothing to Disclose, Linda Chio: Gordian Biotechnology: Employee, Gordian Biotechnology: Stock privately held company, Daniel Fuentes: Nothing to Disclose, Dimitry Popov: Nothing to Disclose, Ian Driver: Nothing to Disclose, Chris Towne: Nothing to Disclose, Francisco LePort: Nothing to Disclose, Martin Borch Jensen: Nothing to Disclose 2067 PHARMACOKINETICS, SAFETY AND EFFICACY OF THE NOVEL NON-BILE ACID FXR AGONIST FXR314 IN PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS: RESULTS FROM A PHASE 2 STUDY Eric Lawitz 1 Kathryn Jean Lucas 2 Kris Kowdley 3 Naim Alkhouri 4 Stephen Harrison 5 Fabrice Piu 6 , 1 Texas Liver Institute, 2 Diabetes & Endocrinology Consultants, PC, 3 Liver Institute Northwest, 4 Arizona Liver Health, 5 University of Oxford, 6 Organovo, Inc Background Farnesoid X receptor (FXR) agonism has demonstrated clinical utility for the treatment of non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) but clinical development has been hampered by limited efficacy and adverse events (pruritus, dyslipidemia)

f-g , Flow cytometry analysis of isolated small intestinal cells from the epithelial layer (left) and lamina propria (centre and right) (n = 8 WT control and allergic, 6 IgE KO control, 5 IgE KO allergic, f ) (n = 11 WT control, 13 WT allergic, 10 IgE KO control, 7 IgE KO allergic, g )