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Some protocols may vary timing based on individual needs, such as daytime Selank administration for stress management with separate evening DSIP dosing, though combined evening administration is most common for addressing stress-related insomnia

If the GP says that she doesn't have macrocytic anaemia so doesn't need this pattern of treatment, you could point out that NICE guidelines for B12 deficiency say that "Note: clinical features of vitamin B12 deficiency can occur without anaemia and without low serum levels of vitamin B12." cks.nice.org.uk/topics/anae

The goal is to significantly reduce the pain within 10 days , even if the pain has been present for a long time

This is why community protocols sometimes combine AHK-Cu serum with microneedling