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Actin microfilament aggregation induced by Withaferin A is mediated by Annexin II

There are sex-based differences in morbidity, rupture risk, and prognosis in patients ( GSTA4 methylation levels than healthy men

This knockdown also induces lactylation at the K73 site in ADP-ribosylation factor 1 (ARF1), which affects vesicle assembly and induces mitochondrial loading abnormalities, thereby blocking the release of mitochondria from astrocytes, ultimately exacerbating the extent of brain infarction in mice

Consequently, its clinical relevance is profound: it provides a mechanistic explanation for the heterogeneous treatment response observed in practice and introduces a measurable pathological processdysregulated lactate metabolismthat can be therapeutically targeted [93]