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The use of AUC in protein studies has undergone two major phases of popularity: a period of initial growth between the 1950s and 1970s (caused by the appearance of commercially available ultracentrifuges), and a resurgence period in the 1990s fueled by significant technological advances including computerized data acquisition, rotor speed, and temperature regulation

22: 120-130, Mar

Mitochondrial dynamics in mammalian health and disease

CD38 is not only a surface marker but also a tightly regulated ectoenzyme expressed in two isoforms ( + to nicotinamide (NAM) and ADP-ribose (ADPR), supporting Ca 2+ influx, proliferation, and mitochondrial stability ( 2+ signaling ( CD38 expression persists across all MM stages, likely reflecting its metabolic and immunoregulatory roles ( + , and cGAMP, that may promote immune tolerance ( Figure 1 )