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For example, piR-1919609 and PIWIL2 was observed to be significantly upregulated in platinum-resistant ovarian cancer tissues

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It may cause damage and apoptosis of TECs through multiple mechanisms, including mitochondrial dysfunction, oxidative stress, regulation of HIF-1, and alteration of extracellular matrix (46)

The choice of route is based on considering the drugs pharmacokinetic properties, convenience of administration and patients health status (Brianna and Lee 2023