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Limitation According to our findings, anti-ferroptosis role of FSP1 is interrupted by inhibiting cell membrane location of FSP1 with the aid of myristoylation inhibitor IMP-366, and then increased nuclear transposition of FSP1 led to ferroptosis-dependent necroptosis in Erastin-cultured leukemic THP-1 cells

Quantitative analysis showed a significant decrease in the number of proliferating cells after 5 mM 3MA treatment at all time points evaluated (Fig

3.2.3 Platelet-to-lymphocyte ratio (PLR) Platelets not only participate in hemostasis but also play an active role in inflammation and tumor progression, capable of secreting various pro-inflammatory and pro-angiogenic factors (95)

Downregulation of these miRNAs in the Ndufs4/ mouse model with LHON-like features resulted in preservation of functional RGCs through a co-activation of mitochondrial biogenesis and mitophagy and improving the visual phenotype [243]