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found that Lipoxin A4 could increase GPX4 levels by activating the ESR2/LPAR3/Nrf2 axis, inhibit FLS ferroptosis, thereby reducing synovial inflammation, alleviating cartilage degeneration, and mitigating pain and pathological progression in knee OA (Hu et al., 2024)

Glutathione quantification by HPLC Human and mouse brain specimens as well as pelleted CHO cells were homogenized in buffer containing 125 mM sucrose, 5 mM TRIS, 1.5 mM EDTA, 0.5% trifluoroacetic acid (TFA) and 0.5% mycophenolic acid (MPA) in mobile phase

IC 50 values and the percentage of viable cells were calculated using SPSS version 25

Nonetheless, the clinical evidence remains inconsistent, as some studies report no significant improvement in symptoms