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Melatonin is secreted mainly by the pineal gland of the brain, and its secretion is extremely high in infants and adolescents and much lower in older individuals

references Akbarzadeh A, Rezaei-Sadabady R, Davaran S, et al

If the choriocapillaris endothelium in AMD is injured by hyperhomocysteinemia the same way as are the retinal capillaries in DR, this would suggest a unifying approach