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Another nuclear receptor, peroxisome proliferator-activated receptor (PPAR-), modulates gene expression related to inflammation and mediates antimycobacterial responses against M.tb infection by activating the expression of genes associated with autophagy, lysosomal function, and phagosomal maturation through lipid catabolism and upregulation of TFEB transcription[54]

however, these patterns differ from those observed between foreign-born groups and U.S.-born whites ( Microbial changes associated with dietary cultural adaptation: among foreign-born Koreans and Hispanics, individuals with high levels of dietary adaptation exhibit intestinal abundances that increasingly resemble those of U.S.-born whites

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doi: 10.1016/S0015-0282(02)04237-1 62 Abd-ElmoatyMASalehRSharmaRAgarwalA