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*Correspondence: Qing-Rong Xia [email protected] This article was submitted to Mood and Anxiety Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

We never use fillers, binders, flow agents, anti-clumping agents, surfactants, colloids, artificial flavors, artificial colors, or any other additives

Biomarkers based on biomolecular mechanisms that can be used for MDD diagnosis, prognosis, and treatment would be useful in providing an objective method for diagnosing MDD rather than a diagnostic method based on subjective evaluation

Data collection and refinement statistics are summarized in Supplementary Table S1