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2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Wang Q

Furthermore, compared to ICS given as a monotherapy, LABAs have the ability increases glucocorticoid-dependent gene expression and which might explain some of the benefits of LABA/ICS combination therapy (Sriprasart et al

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The oral bioavailability is equal to the product of the fraction of the dose that is absorbed from the gut (f g ) and the fraction of that absorbed portion that then escapes from the liver (f H )