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They may use a fine needle and apply local anesthetic before treatment to minimize patient discomfort

However, the SAPNets are based on understandable descriptors (e.g., size, shape, aspect-ratio, and type of coating) and do not require additional computational calculations, allows consideration in environmental influence (such as solvent and pH), and the users can easily see how the change of the descriptor values will influence the predicted toxicity

Side effects may include local injection site reactions, gastrointestinal disturbances, hypersensitivity reactions, hemolytic anemia in G6PD-deficient patients, and kidney stone formation in susceptible individuals

[10] Do not hold your thumb over the plunger of the syringe until you're certain that the needle is inserted correctly