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The expression of ERK, p38 MAPK, and AP-1 can increase transcriptional activity within the NF-kB pathway, consequently triggering skin inflammation and accelerating the process of skin aging (87)

Similarly, case series by Gerson Institute staff published in the alternative medical literature suffered from methodological flaws, and no independent entity has been able to reproduce the claims

Notably, the inter-atomic S-O distance between the H-site bound GSH and water molecule was 3.6 , which is slightly greater than the expected hydrogen bond length as a nucleophile