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By inhibiting lipid ROS generation and the hyperpolarization of mitochondrial membrane potential, mitoglitazone could restore mitochondrial DNA copy number, the generation of ATP, and mitochondrial morphology in kidney tissue, inhibiting mitochondrial dysfunction and ferroptosis induced by I/R

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Additionally, several factorssuch as hemodynamics, targeting efficiency, and the physicochemical stability of the nanomaterialscan influence their in vivo distribution during PAI