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Vitamin B12, also known as cobalamin, is a water-soluble vitamin essential for: Red blood cell formation Nervous system health DNA synthesis Brain function Energy metabolism A lack of vitamin B12 can lead to symptoms such as fatigue, depression, and memory problems, and if left untreated, it may even cause lasting neurological damage

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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the invention encompasses use of one or more cations of the invention to modulate stem cell differentiation