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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

Since B12 plays a role in reducing homocysteine levels and promoting heart health, it may indirectly support erectile function by improving circulation and vascular health

In the research literature and in usage reports, DSIP is employed in comparatively low microgram quantities