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Targeting ferroptosis: Paving new roads for drug design and discovery

Lab Invest (2000) 80:44354

Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet MA, et al

Initial high-throughput compound screening and further medicinal chemistry-based optimization developed two novel series of phenylurea-based compounds inhibiting GOT1 enzymatic activity with potencies in the low micromolar IC 50 range 155