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While increased surface area and dense ligand presentation can enhance local drug concentration and enable sustained, controlled release, these same features can intensify chemical interactions with host cells and increase toxicity [148]

4 Strategies for targeting the TME 4.1 Targeting the physical microenvironment 4.1.1 Targeting hypoxia Hypoxia is a state of low oxygen, and the most direct way to solve this problem is to increase the level of oxygen in the tumor through oxygen delivery or oxygen production

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by Hannah Frye This tiny, portable wand feels great on the skin but provides less coverage than full-face LED masks