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The unbiased, consecutive recruitment may have introduced different disease endotypes or subtypes

And since the misfolded proteins present in the SOD1 population can sometimes be found in people without these genetic mutations, others have launched a small trial to see whether tofersen can help in those far more common cases of sporadic ALS

Diet quality and protein-bound uraemic toxins: investigation of novel risk factors and the role of microbiome in chronic kidney disease

I have personally used it for acute injuries and have found it effective, particularly when the injury involves soft tissue rather than advanced joint degeneration