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All animal experiments were approved by the Institutional Animal Care and Use Committee at the Institute of Biophysics, Chinese Academy of Science

Tumor proteome analysis Tumor proteome data were generated as part of a previous study 7 and was reanalyzed for this study

In addition, in the ARDS model, ACE2 knockout mice displayed more severe symptoms of respiratory shut down compared with wild-type mice [43]

Anti-inflammatory activity Curcumin has been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS)