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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Chuang C.Y., Shi Y.C., You H.P., Lo Y.H., Pan T.M

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130,131,174 Translocated LPS reaches the liver via the portal vein, is recognized by TLR4 on the surface of liver sinusoidal endothelial cells and Kupffer cells, activates the downstream MyD88/NF-B signaling pathway, triggers a strong pro-inflammatory response, releases large amounts of cytokines such as TNF-, IL-1, and IL-6, and exacerbates liver inflammation and cell injury