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Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

Notably, animal models treated with pifithrin- p-nitro (PFT) (a p53 inhibitor) present decreased steatosis, oxidative stress, apoptosis, and insulin resistance

Furthermore, as patients on B12 therapy were excluded from the study and intestinal absorption capacity for B12 is limited, they hypothesized that elevated levels are directly related to malignization

10.3390/biomedicines10040891 Biomedicines 165 WeiC