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When the body is overwhelmed by viral infections, chronic inflammation, or environmental toxicants, this ratio plummets

Hwang et al

Genes Nutr 2014, 9:435 DeClerc etal

The presence of cardiac dysfunction in diabetes is accompanied by overload of intracellular calcium in cardiomyocytes ( 2+ channels, followed by the release of Ca 2+ from the sarcoplasmic reticulum (SR) via the ryanodine receptor (RyR2), leading to actinmyosin interaction