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Reproductive toxicity studies of acetylcysteine in the rat given oral doses of acetylcysteine up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature1

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Furthermore, a dose of 80 mg/kg of piperine not only reduced the clinical and histopathological symptoms, nitric oxide levels, and increased IDO activity in eye homogenates more effectively than the other two doses of piperine but also improved weight gain in EAU rats better than the 20 mg/kg dose