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The extensive metabolism of PROTACs by CYP3A4 demonstrated in this work, while perhaps unsurprising given the enzymes flexible substrate pocket, nevertheless presents a drug-drug interaction risk (Zhou Citation2008)

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The intracellular lactate dehydrogenase (LDH) activity of living cells is relatively constant during the culture, while impaired cells lead to LDH leakage to the culture medium ( 2 O 2 , either in the presence or absence of peptides, was determined by using the spectrophotometric method