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56 As the disease progresses, defects in fatty acid oxidation due to the repression of transcription factors, such as sterol regulatory element-binding proteins and peroxisome proliferator-activated receptor-, result in energy depletion and the release of mitochondrial RNA/DNA, activating inflammatory pathways involving interferon regulatory transcription factor and transforming growth factor-beta (TGF-)

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Non-surgical Treatment The limitations of surgical interventions for cataracts have driven research towards non-surgical treatment strategies