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As you begin to age, the skin loses elasticity and eventually gets loose or saggy in various parts of the body, which leads to visible cellulite

Graves disease Graves disease is an autoimmune disorder that causes hyperthyroidism, causing it to make more thyroid hormone than your body needs

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It is noteworthy that during the initial phase of functional impairment in certain organs, such as liver injury, kidney injury, and cardiovascular disease, increased intestinal permeability and endotoxin release can be detected, which helps to identify some high-risk adverse events early (Lee et al., 2018)